Measures to prevent ARNTL degradation or inhibit Egln2 activation can destroy the stability of HIF1A and promote the ferroptosis of tumor cells.[82, 83] Sequestosome 1(SQSTM1) is a multifunctional cargo receptor implicated in the autophagic degradation of ubiquitinated substrates, including proteins and organelles. Here, SQSTM1 is linked to neoplasm.