NCOA4 and Sepsis: The NCOA4-ferritin axis modulates intracellular iron homeostasis in accordance with cellular iron availability.[62, 63] In the LPS induced sepsis myocardial injury model, we can see that the protein changes of NCOA4 and ferritin are closely related in a time-dependent manner.[62] LPS promotes the expression of NCOA4 and interaction between ferritin, which eventually leads to ferroptosis.