IL6R and diabetic kidney disease: The UK Biobank further confirmed its association with the human leukocyte antigen (HLA) region.[37] The rs 10737680 is also reported to be associated with interleukin-6 receptor.[38] These results may provide evidence for the causal role of DR in the development of DKD, since inflammatory factors cause lesions in renal function in patients with DR, while the effects of confounding factors are minimized.