Pan-cancer analyses enable the investigation of the differential expression of target genes and the corresponding abnormal regulatory mechanisms essential for tumorigenesis and progression across multiple layers of alterations.[18] To our knowledge, this is the first pan-cancer study regarding the oncogenic role of GOLT1B by comprehensively assessing gene expression, clinical association, survival status, DNA methylation, genetic alterations, immune infiltration, and relevant molecular mechanisms. Here, GOLT1B is linked to cancer.