GOT1 and cancer: Membrane trafficking defects resulting from anomalous changes in resident proteins are closely associated with cell signaling communication, dissociation and invasion, immune regulation, and metastasis in cancer.[9] Golgi transport 1B (GOLT1B) is a member of the GOT1 family, and abnormal expressions of proteins in this family are associated with GA membrane trafficking disorders and cellular malignant behaviors.[10] The GOT1 family consists of two primary members, GOLT1A and GOLT1B.