BECN1 and Erythema: Significant correlations were observed between the increase in Beclin-1 levels in skin biopsies and various biophysical parameters, including skin hydration (Spearman’s rho = 0.47; p < 0.05), TEWL (Spearman’s rho = -0.51; p < 0.05), melanin index (Spearman’s rho = -0.42; p < 0.05), and erythema index (Spearman’s rho = -0.56; p < 0.05).