Several predictors of preeclampsia must also be considered; these are human chorionic gonadotropin (hCG), alfa-fetoprotein (AFP), estriol, pregnancy-associated plasma protein A (PAPP A), inhibin A, activin A, kisspeptin, C-reactive protein, cytokines, placental growth factor, vascular endothelial growth factor (VEGF), FMS-like tyrosine kinase receptor-1 (sFlt-1), endoglin, antithrombin-3, atrial natriuretic peptide (ANP), and 25-hydroxyvitamin D (vit D3) [5]. The gene discussed is NPPA; the disease is preeclampsia.