Syndecans are involved in several signaling pathways, including ERK/MAPK (Hara et al., 2021), AKT/mTOR/S6K1, and Wnt signaling (Luyten et al., 2008; Jones et al., 2020; Hara et al., 2021; Johnson de Sousa Brito et al., 2021; Jones et al., 2022); however, none of them have previously been investigated in the context of WB myopathy. The gene discussed is SDC1; the disease is myopathy.