Syndecans and their role in fibrosis have primarily been studied in relation to cancer (Cheng et al., 2016), cardiac (Lunde et al., 2016; Herum et al., 2020), and lung fibrosis (Parimon et al., 2019) and skeletal muscle aging in mice (Pisconti et al., 2016). The gene discussed is SDC1; the disease is cancer.