(17) reported that the GCM2 p.Tyr394Ser rs142287570 variant was found in 41% and 27% of Ashkenazi Jews (AJ) with FIHP kindreds and sporadic PHPT in their referral cohort, respectively, and at a lower prevalence in other European origin individuals. The gene discussed is GCM2; the disease is familial isolated hyperparathyroidism.