Interestingly, we found that in tumours where IRF‐score could be a protective factor such as LIHC, LUAD, HNSC, UCEC, CESC and THCA, effector immune cells represented by CD8+ T cells were significantly more infiltrated in high score group, while immunosuppressive cells represented by M2 macrophages were mostly enriched in low IRF‐score (Figure S6B–G). Here, TRIM63 is linked to neoplasm.