To further characterize IRFs biology in pan‐cancer, we constructed IRF‐score based on ssGSEA and identified that IRF‐score were significantly more expressed in BRCA, CESC, GBM, HNSC, KIRC, KIRP, LUAD, THCA and UCEC than normal samples, while the opposite was true in COAD, KICH and LIHC. Here, TRIM63 is linked to glioblastoma.