Since we have shown that CO extracts can induce the Keap1/Nrf2 pathway and promote the stimulation of important antioxidant response genes such as HO‐1 and SOD 1/2 in a pancreatic β‐cell line [12], we wanted to extrapolate these prior findings into in vivo models of T1D to initially determine potential clinical efficacy. This evidence concerns the gene KEAP1 and type 1 diabetes mellitus.