TGFB1I1 and amyotrophic lateral sclerosis: In fact, the signature of this cluster contained several neuroprotective microglial secretory markers (IL4R, TGFB1I1, TGFBI, CD163) [48], as well as the MMP9 metalloproteinase gene, whose knockdown slows disease progression in ALS mutant models [49–51].