We further identified several candidate genes that may drive proinflammatory properties of microglia, including IL-27, CXCL11 and ADAM8. The levels of IL-27 were elevated in MS brain tissues [68, 69] and it promoted the expression of CXCL9, CXCL10, and ICAM-1 in astrocytes [70]. Here, ADAM8 is linked to myeloid sarcoma.