Deletion of MEF2C was observed in a DSS-induced mouse colitis model, resulting in downregulation of M1 macrophage marker expression, with dual luciferase reporter assays on macrophages demonstrating that MEF2C binds directly to the promoters of IL12a and IL12b to facilitate M1 polarization in macrophages [25] (Fig. 4a). This evidence concerns the gene MEF2C and colitis.