Thus, the periodontitis model of rats was established by periodontal ligation and a P.g-LPS-stimulated visceral adipocytes model in vitro, and the association of IRE1α-mediated ERS with hypoadiponectinemia was explored to preliminarily reveal the underlying mechanism behind hypoadiponectinemia caused by periodontitis in this study. The gene discussed is ERN1; the disease is adiponectin deficiency.