For example, RBP Quaking (QKI) may interact with the QKI response elements in the flanking introns of some circRNAs and thereby promoting the biogenesis of these circRNAs [10, 11]; circDLC1 functions as a tumor suppressor via binding to RNA-binding protein HuR, blocking the interaction between HuR and MMP1 mRNAs to restrain MMP1 expression in a competitive manner [12]. This evidence concerns the gene MMP1 and neoplasm.