Then, according to a comprehensive literature review [29, 38, 55], among the miRNAs involved in diabetes, especially in the hippocampus, we selected miR-34a, which is also present in the miRWalk 3 and has the validated diagnostic assay (http://mirwalk.umm.uni-heidelberg.de/rat/gene/309757/?page=9). We prepared a list of miRNAs that target p66Shc, CASP3, and PARP1 using miRWalk, miRDB, miRmap (https://mirmap.ezlab.org/), and miRTarBase (https://mirtarbase.cuhk.edu.cn/~miRTarBase/miRTarBase_2022/php/search.php) databases. The gene discussed is CASP3; the disease is diabetes mellitus.