RNPC3 and liver disorder: Tao et al. loaded Cas9 ribonucleoprotein (RNP) into purified exosomes isolated from hepatic stellate cells by electroporation, and found that this facilitated efficient cytoplasmic delivery of RNP while allowing RNP to accumulate specifically in liver tissue in vivo, which in turn facilitated tissue-specific gene therapy for liver disease, as depicted in Fig. 3 [35].