C4b-binding protein alpha chain (Bonferroni p-value = 4.0E − 02) and apolipoprotein B-100 (p = 3.4E − 02) were associated with the PRS of CAD, with apolipoprotein B-100 being genetically correlated to BMI (rA = 0.32). Here, APOB is linked to coronary artery disorder.