Overexpression of Progranulin (encoded by the PGRN gene, located at chromosome 17 - NC_000017.11 (44,345,302..44353106)) in the epidermal keratinocytes of psoriasis patients, and elevated serum levels in patients with lesional psoriatic skin have suggested a therapeutic role of progranulin in regulating inflammation [13, 23, 24]. This evidence concerns the gene GRN and psoriasis.