We noticed an inverse correlation between LIPT2 expression and TMB in BRCA, Stomach and Esophageal carcinoma (STES), STAD, THYM, CHOL, and DLBC (Fig. 6a), and an inverse correlation between LIPT2 expression and MSI in GBMLGG, STES, STAD, THYM, and THCA, while a positive correlation was found in UVM (Fig. 6b). This evidence concerns the gene LIPT2 and digestive system neoplasm.