Oesophageal cancer is a top candidate as it has been shown that accumulated DNA Damage repair (positive staining for γH2AX and phospho-ATM) was evident within tumour tissue and significantly increased in non-malignant tissue surrounding the tumour cells although activation of p53 by phosphorylation at serine 15 was observed only in tumour tissue ([32]) highlighting the opportunity for enhancing tumour kill without normal tissue damage when radiation is used. The gene discussed is ATM; the disease is neoplasm.