Inhibition of PTP1B also counteracted the changes in the HOMA-IR index observed in Bach1LTG mice (Fig. 7b, right), improved glucose tolerance, insulin tolerance, and hepatic function, as well as reduced liver lipid accumulation in Bach1LTG mice (Fig. 7c, d, Supplementary Fig. 12b–i). This evidence concerns the gene PTPN1 and glucose measurement.