In HCC CTCs, USP1 can reduce the degradation of transducin beta-like 1 X-linked receptor 1 (TBLR1) by deubiquitination, activate the Wnt signaling pathway, and prevent CTCs from undergoing apoptosis.293 Therefore, USP1 inhibitors can target CTCs to inhibit the occurrence of metastasis. Here, TBL1XR1 is linked to hepatocellular carcinoma.