TGFB1 and neoplasm: TGF-β derived from platelets is an important source of the EMT process that prompts CTCs to transform into a more invasive phenotype.252–254 Richard O. Hynes et al. demonstrated that the NF-kB/MCP-1 pathway activated by direct adhesion of platelets cooperates with platelet-derived TGF-β, facilitating the extravasation of tumor cells injected into the blood circulation out of vessels and promoting lung colonization.