EGFR and non-small cell lung carcinoma: Tribbles Pseudokinase 3 (TRIB3), a stress sensor, interacts with EGFR, promoting its phosphorylation at T654 via PKCα and its ubiquitination at K689 through WWP1, thus leading to EGFR recycling, stability, and downstream activation of EGFR and NSCLC stemness.