Moreover, Ac-iNKT1 cells showed similar gene expression profiles to terminally differentiated CD8+ effector T cells (TE) (Supplementary Fig. 5o, p)43, indicating that Ac-iNKT1 cells would play key roles to kill enlarged and inflamed adipocytes in obesity. The gene discussed is CD8A; the disease is obesity due to melanocortin 4 receptor deficiency.