However, in one study, immunofluorescence staining of bone marrow sections of MM mice showed that Treg cells were highly accumulated at the tumor location, and expressed higher levels of CD25, ICAM-1, CD69, CD44 and co-inhibitory receptors Lag-3, Tim-3, TIGIT and PD-1 [81]. The gene discussed is IL2RA; the disease is neoplasm.