In vitro studies have shown that MM cells can induce IL-10 production by nTreg cells and promote significant proliferation of CD4+CD25+Foxp3+ iTreg cells in a contact-dependent manner, showing increased expression of Foxp3, GITR, PD1 and CD62L compared with nTreg cells [75, 76]. The gene discussed is TNFRSF18; the disease is Miyoshi myopathy.