Upregulation of E3 ubiquitin ligase RNF115/BCA2—also known as Rab7-interacting RING finger protein (Rabring7), widely expressed in various tissues—is observed in different carcinomas, including breast cancer [15], lung cancer [16], and gastric cancer [17] and is negatively correlated with prognosis. The gene discussed is RNF115; the disease is lung carcinoma.