Overproduction of reactive nitrogen species (RNS) markers, such as neuronal nitric oxide synthase and inducible NOS (iNOS), are shown to mediate seizures-induced extensive brain injuries and functional deficits in epilepsy models (Beamer et al., 2012; Puttachary et al., 2016b), including an organophosphate toxicity model (Putra et al., 2020c). This evidence concerns the gene NOS2 and epilepsy.