MTHFR and cardiovascular disorder: Indeed, the metabolome is strongly influenced by dietary intakes -- genetic variants can influence diet intakes, and dietary intakes can reveal or obscure metabolite-disease relationships, such as in the case of the methylenetetrahydrofolate reductase (MTHFR) C477T variant, its interaction with dietary folate/folic acid intake, and the risk of elevated homocysteine and cardiovascular disease.