At the first stage, we assessed the basic level of gene expression and induction of the Atox1 protein in HCT116 colorectal cancer and A549 lung carcinoma cell lines with the wild type (WT) or inactivated by the CRISPR-Cas9 tumor suppressor gene TP53 (TP53-/-). The gene discussed is ATOX1; the disease is lung carcinoma.