It is tempting to speculate that the STEC type III secretion system (T3SS) is implicated since our results indicated that NLRP3 is involved in IL-1β secretion, and previous studies showed that Salmonella enterica induces NLRP3 activation upon THP-1 infection associated with the activity of the T3SS [38]. The gene discussed is SGCG; the disease is infection.