Our study findings have shown that serum BMP8B levels were positively correlated with ALP, APRI, and FIB-4 in NAFLD patients, AST, ALT, APRI, and FIB-4 in NASH patients, whereas, a negative correlation was observed with HDL in NAFL patients. The gene discussed is BMP8B; the disease is metabolic dysfunction-associated steatotic liver disease.