Since most cancers have abnormalities in the p53 gene signaling pathway, inactivation of the p53 gene allows tumor cells to escape apoptosis and is strongly associated with malignancy development, prognosis, and resistance to radiotherapy, all of these factors contribute to make the tumor suppressor gene P53 a promising target for gene therapy [36].The concept of how to put wild type (WT) p53 back into cancer cells leads to the regression of tumor cells has facilitated the development of recombinant adenoviruses carrying wild p53 genes. Here, TP53 is linked to cancer.