RAd-p53 can transfer the p53 gene into tumor cells via adenovirus to reconstruct the p53 gene function of tumor cells and cause programmed death or severe dormancy of tumor cells, thus improving the anti-tumor efficacy [16].Studies have shown that recombinant human p53 adenovirus can effectively enhance the immune function of the body, and the combination with TACE in the treatment of primary liver cancer can make up for the shortcomings of monotherapy [17]. This evidence concerns the gene TP53 and liver cancer.