We also analyzed the relationship between ferroptosis subtypes, ferroptosis genomic subtypes and interleukin factors and found that IL5, IL13 and IL33 were differentially expressed in both ferroptosis subtypes and ferroptosis genomic subtypes, suggesting that interleukins may be a feature of both ferroptosis subtypes and that different interleukin factors are involved in PD progression in different subtypes (Fig 11E–11F). This evidence concerns the gene IL33 and Parkinson disease.