Because ACSL4 can esterify PUFAs as a substrate for lipid peroxidation, which further triggers ferroptosis, and because polyunsaturated fatty acids play a crucial role in neuronal function, ACSL4 is considered to be a key gene in the pathogenesis of a variety of neurological disorders, including ischemic stroke and multiple sclerosis [105]. This evidence concerns the gene ACSL4 and nervous system disorder.