IL13RA1 and Parkinson disease: Single nucleotide polymorphisms of interleukin 13 (IL-13) and its receptor α1 (IL-13Rα1) in sporadic PD have been found to increase cellular susceptibility to OS and to increase the cytotoxic activity of IL-13 on human SH-SY5Y neurons exposed to sublethal doses of hydrogen peroxide, tert-butyl hydroperoxide, or the seed ferroptosis inducer RLS3 [132].