Differential expression analysis between MG from tumor center and periphery revealed downregulation of inflammatory-related genes in the peripheral MG (FCGBP and CCL20), downregulation of genes associated with canonical interferon (IFN) responses (IFI6, IFI27, STAT1, ISG15), and cell proliferation (STMN1) as well as downregulation of scavenger receptor gene CD163 (Figure 3A and Supplementary file 4). This evidence concerns the gene ISG15 and neoplasm.