And lastly, CD8+ T cells in the tumor periphery exhibited a transcription factor profile of exhausted T cells with high expression of NR4A1, MAF, and IRF4 (Figure 6G and Figure 6—figure supplement 1C), which were implicated in T cell dysfunction and exhaustion (Ma et al., 2019; Liu et al., 2019). This evidence concerns the gene CD8A and neoplasm.