CDH2 and melanoma: Consistent with this, Qi et al. documented that phosphorylation of N-cadherin by Src-kinase on Tyr-860 abolishes its ability to bind β-catenin at the plasma membrane of melanoma cells, inhibiting their transmigration across the endothelium (33), while Tyr phosphorylation of N-cadherin promotes its proteolytic cleavage and diminishes cell adhesion (32).