OBSCN and familial dilated cardiomyopathy: It is important to note that of the approximately 20 known OBSCN variants linked to the development of heart disease, 3 immediately flank kin1 and are associated with the development of left ventricular noncompaction cardiomyopathy or DCM, while 1 resides within the kin1 catalytic domain, possibly affecting its enzymatic activity and/or substrate specificity and is associated with the development of DCM.