ARSA and neoplasm: This was abrogated by bafilomycin A1, which blocks endosomal/lysosomal processing, and by blockade (or KO) of arylsulfatase A, which can cleave the sulfate moiety, suggesting that the tumor protection afforded by C24:2 in vivo may depend not on altered stimulation of type II NKT cells but on altered specificity for different target cells caused by lysosomal processing to stimulate type I NKT cells, in addition to inducing the activation and expansion of cDC1 cells.