APOB and colorectal carcinoma: Another key finding in the reverse MR analysis was that genetic liability to CRC was associated with increased levels of total cholesterol, VLDL-cholesterol, LDL-cholesterol, and apolipoprotein B, though we find little evidence for a causal effect of these traits on risk of CRC in the forward MR, replicating previous forward MR analyses for total and LDL-cholesterol (Gui et al., 2023; Rodriguez-Broadbent et al., 2017; Cornish et al., 2020; Luo et al., 2021).