Genetically proxied lipid-lowering variants of LDLR (OR 1.15; 95% CI: 1.08 to 1.23; p-IVW=2.86×10-5, FDR=2.99×10-4), HMGCR (OR 1.29; 95% CI: 1.13 to 1.45; p-IVW=9.71×10-5, FDR=7.62×10-4), and APOB (OR 1.09; 95% CI: 1.16 to 1.03; p-IVW=2.92×10-3, FDR=1.48×10-2) were associated with increased risks of T2D. This evidence concerns the gene APOB and type 2 diabetes mellitus.