In the positive control analysis (Figure 3), we identified significant associations between most lipid-lowering gene targets (HMGCR, LDLR, PCSK9, NPC1L1, and LPL) and a decreased risk of both coronary atherosclerosis and major coronary heart disease (CHD) events, except for APOB, CETP, and APOC3 (only associated with reduced coronary atherosclerosis risks) and ANGPTL3 (no association with either CHD or coronary atherosclerosis). Here, NPC1L1 is linked to coronary atherosclerosis.