SERPINE1 and female reproductive system disorder: Interestingly, we noticed a prominent enrichment of the overlapped upregulated genes related to inflammatory responses, including serpin serine protease inhibitors (SERPINE1 and SERPINF1) and components of the complement system (C3 and C1QA) (Fig. 7C), suggesting a putative common role of elevation of inflammation in the regulation of NHP ovarian aging and female reproductive diseases.