Conversely, several downregulated genes crucial for folliculogenesis were also found to be linked to ovarian diseases, namely, genes for sex hormone biosynthesis such as STAR, CYP17A1, and ALDH1A1 (Burris-Hiday and Scott, 2021; Petrosino et al., 2014) (Fig. 7C), along with genes required for follicle development, such as INHA (Lovell et al., 2003) (Fig. 7C). Here, ALDH1A1 is linked to ovarian disorder.