Conversely, several downregulated genes crucial for folliculogenesis were also found to be linked to ovarian diseases, namely, genes for sex hormone biosynthesis such as STAR, CYP17A1, and ALDH1A1 (Burris-Hiday and Scott, 2021; Petrosino et al., 2014) (Fig. 7C), along with genes required for follicle development, such as INHA (Lovell et al., 2003) (Fig. 7C). This evidence concerns the gene CYP17A1 and ovarian disorder.