Because of the AML-specific requirement for the BRD9 bromodomain and the precise regulation of Myc through its AML-specific enhancers—but not all myeloid enhancers—we hypothesize that BRD9 is responsible for maintenance of an AML-specific subset of genes—including Myc—through gene-distal regulation. This evidence concerns the gene BRD9 and acute myeloid leukemia.