While large-scale screens have identified BAF complex subunits as leukemia-specific dependencies (64, 133) and BAF complex ATPase inhibitors have shown ability to selectively inhibiting leukemia cell growth (8), the BAF complex has essential roles in normal hematopoiesis (51, 61, 134), complicating the process of targeting BAF ATPases for treating AML. The gene discussed is DNAH8; the disease is acute myeloid leukemia.