A strong association between PD-L1 predicted scores and response to ICIs is observed in both NSCLC-MSK cohort [HR: 1.4 (95% CI: 1–1.8), P = 0.03] and pan-cancer-VHIO cohort [HR: 1.5 (95% CI: 1–2.3), P = 0.049], as measured by Cox regression analysis. This evidence concerns the gene CD274 and non-small cell lung carcinoma.