The gene set enrichment analysis (GSEA) demonstrated 8b down‐regulated NF‐κB signaling pathway in LPS‐stimulated macrophages (Figure 4C).[14] NF‐κB is a crucial pro‐inflammatory signaling pathway and usually serves as a therapeutic target in the treatment of inflammatory and auto‐immune diseases. The gene discussed is NFKB1; the disease is immune system disorder.