UBC12, one of the two NEDD8‐conjugating enzyme E2s identified as far, has been assumed as an alternative therapeutic target for neddylation pathway inactivation in lung cancer.[52] Transcriptional regulation of UBC12 mRNA expression by HIF‐1α and c‐jun has been reported in lung cancer cells in response to stress.[32] However, how the degradation process or protein stability of UBC12 is regulated in cancer cells has never been disclosed. This evidence concerns the gene HIF1A and lung cancer.