The major protein degradation pathways in cells include the ubiquitin‐proteasome system (UPS) and autophagy‐lysosome pathway.[33] To determine which pathway is mainly involved in UBC12 protein degradation in breast cancer, we respectively treated breast cancer cells with proteasome specific inhibitor (MG132) and lysosome specific inhibitor (Bafilomycin A1, BafA1) and monitored UBC12 protein level change. This evidence concerns the gene UBE2M and breast cancer.