demonstrated that high level of NNMT in CAFs resulted in the depletion of S‐adenosyl methionine and a decrease in histone methylation, leading to extensive gene expression changes in the tumor stroma.[14] Although these studies on NNMT are performed in different types of tumors, the mechanisms suggest that NNMT regulates tumor‐associated protein modifications by depleting intracellular SAM and NAM, thereby promoting tumorigenesis. Here, NNMT is linked to neoplasm.