Meder et al. (6) identified a pathway driving the pathogenesis of the SCLC involving activation of the NOTCH target achaete‐scute homolog 1 (ASCL1) and its ligand delta-like protein 3 (DLL3) and canonical WNT‐signaling in the context of mutual bi‐allelic RB1 and TP53 lesions. The gene discussed is RB1; the disease is small cell lung carcinoma.