Our observations demonstrated that ACE, N-BOC, and DFU promoted SOD3 and iNOS expression in macrophages infected with Mtb. Also, in other reports, valproic acid induced iNOS and high levels of NO in macrophages infected with Mtb. 29Thus, this is the first report on SOD3 induction by HDACi treatment during Mtb infection, similar results have been reported elsewhere in Salmonella typhimurium or Escherichia coli infection.30 This evidence concerns the gene ACE and escherichia coli infection.