Our results are supported by studies that have associated ALPK1 single-nucleotide polymorphisms (SNPs) and expression with various chronic inflammatory diseases and different cancers, including CRC.36–40 Interestingly, recent studies have revealed links between bacteria, including Fusobacterium and a wide range of solid tumors including breast, skin, and pancreatic cancers. Here, ALPK1 is linked to pancreatic neoplasm.