GSEA analysis revealed a significant enrichment of genes involved in metabolism (including cysteine and methionine metabolism, fatty acid metabolism, arginine and proline metabolism), aggrephagy, ATP-binding cassette (ABC) transporters, EGFR signaling and multiple myeloma CD1 and CD2 molecular subgroups (23) (Supplementary Figure S2). This evidence concerns the gene CD2 and AL amyloidosis.