Notably, we found that the expression of mitochondrial structure- and function-related proteins (Ampkα2, Ucp1, Nd5, and Sirt3) was downregulated by BLM exposure, and this change was restored by VE treatment significantly or in a trend, strongly suggesting that VE improves the structure and function of BLM-damaged mitochondria. The gene discussed is MT-ND5; the disease is Bloom syndrome.