We specifically focused on genes that are known to be mutated in human ARPKD (PKHD1/Pkhd1), in cpk mice (CYS1/Cys1), as well as necdin (NDN/Ndn), which we have previously shown regulates Myc expression (Wu et al., 2013). Here, CYS1 is linked to autosomal recessive polycystic kidney disease.