We specifically focused on genes that are known to be mutated in human ARPKD (PKHD1/Pkhd1), in cpk mice (CYS1/Cys1), as well as necdin (NDN/Ndn), which we have previously shown regulates Myc expression (Wu et al., 2013). This evidence concerns the gene PIK3C2A and autosomal recessive polycystic kidney disease.