Monogenic epilepsies can be characterized according to the gene function affected: Impaired function of ion channels (e.g., CACNA1A), receptors (e.g., GABRB3), transporters (e.g., SLC2A1), synapse-related (e.g., PRRT2), and other pathways (e.g., CDKL5, PCDH19) are associated with epilepsy. This evidence concerns the gene PRRT2 and epilepsy.