Diagnostic findings in syndromic vs. non-syndromic patients revealed a significant overlap of frequent causes of monogenic epilepsies including SCN1A, CACNA1A, and SETD1B (Figure 4A), thereby confirming the heterogeneity of the associated conditions and demonstrating the variety of causative genes in syndromic epilepsy (Figure 4B). The gene discussed is CACNA1A; the disease is epilepsy.